Phage Surface Display Service

Phage surface display (PSD) technology is an in vitro cloning and recombinant expression technology for single gene manipulation. Using this technology, the coding sequence of foreign peptide (or protein) is integrated into the phage genome and displayed on the phage surface in the form of fusion protein. The comprehensive functional identification is carried out through affinity screening. The remarkable feature is the formation of "genotype-phenotype coupling", which combines the recombinant protein screening and gene screening. At present, this technology has been applied in many fields.

Creative BioMart has developed a complete phage surface display system, which can provide customized services for scientists.

Technology Advantages

The main advantage of the PSD technology is that it can simplify the structure, stability, versatility and reliability of phage. Compared with other surface display systems, the characteristic of PSD is that it not only displays antibody fragments on the surface, but also encodes corresponding genes in its genome. This allows rapid enrichment of antigen-specific binders and amplification in their corresponding hosts. Other advantages of phage display include:

• The ability of antibody cross-reactivity can be regulated
• The antibody sequence is easy to obtain
• Suitable for toxic and non-immunogenic antigens
• Support the rapid construction of the original high diversity library
• No animal immunization is required

Technology Applications

PSD has a wide range of applications, including but not limited to

• Study on protein-ligand interaction
• Development of antibody function
• Therapeutic, diagnostic, research or catalytic antibody discovery
• Improve the affinity of an antibody to a specific target and/or improve its biophysical properties to improve its exploitability
• It can display peptide and screen-specific antibody
• The epitope mapping

What We can do for Our Clients?

• Phage Surface Display Platforms

We not only produce all kinds of antibodies based on M13 phage display system for customers, but also accept customers' requirements to produce antibodies or proteins in T4 phage display system or T7 phage display system.

• Construction of Phage Library

Based on phage display technology, we can provide you with natural, semi-synthetic, and fully synthetic peptide libraries as well as various types of cDNA libraries.

• Phage Antibody Library

Based on the advanced phage platform, we can produce high affinity and high specificity antibodies, including nano antibody, double-antibody, chimeric antibody (such as humanized antibody), VHH single domain antibody and special monoclonal antibody.

Customers who need our assistance are more than welcome to contact us or submit an online inquiry. Our professional team will provide you with detailed guidance and solution ASAP.