Endotoxins are the lipopolysaccharides (LPS) in the cell wall of gram-negative bacteria. Endotoxin can induce a strong immune response. For customers who need to perform in vivo experiments (such as protein vaccine development and immune cell-based testing), we recommend that you add Creative BioMart's endotoxin removal and detection services to your protein expression service package. We will provide effective endotoxin removal solutions, which can significantly reduce endotoxin levels during the production of recombinant protein to meet the strict endotoxin control requirements.
Creative BioMart provides a one-stop low endotoxin protein production solution, which includes protein expression and purification and endotoxin removal service. The whole process of protein expression is strictly controlled. Endotoxins will be removed from all instruments and reagents used in the experiment to ensure a low endotoxin level in the environment.
| SERVICE STEP | DESCRIPTION |
| Project evaluation and program building |
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| Endotoxin removal | Endotoxin removal by customized process |
| Endotoxin quantitative test |
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Creative BioMart has developed a series of methods to remove endotoxin. After project evaluation, we will draft a customized endotoxin removal scheme for your target protein, using one method or a combination of methods to ensure the highest efficiency.
| TECHNOLOGY | ENDOTOXIN REMOVAL EFFICIENCY | PROTEIN RECOVERY RATE |
| Ion exchange chromatography | 99%, low cost, high adsorption capacity | At least 80% |
| Affinity chromatography | 90%-98%, high efficiency and selectivity | 40%-85% |
If necessary, we can also use other endotoxin removal methods like liquid phase separation method, molecular sieve method, ultrafiltration method, adsorption method, distillation method, or hydrophobic chromatography method. Please contact us and let us know your needs.
We provide different levels of endotoxin removal services to meet the needs of customers.
| ENDOTOXIN REMOVAL LEVEL | DETAIL |
| Low | Endotoxin ≤1EU/μg |
| Middle | Endotoxin ≤0.1EU/μg |
| High | Endotoxin ≤0.01EU/μg |
Customers who need our assistance are more than welcome to contact us or submit an online inquiry. Our professional team will provide you with detailed guidance and solution ASAP. If you have any special needs or are interested in learning more about Creative BioMart's protein expression services, please feel free to inquire about more details.
